Ethanol → HCID 18520475, compound

HRID 1368782Notes

Reaction equation

HRID 1368782 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[N:5]=[C:4]([NH:18][NH2:19])[N:3]=1.[CH2:20](O)C.[CH3:23][CH:24](C)[C:25](=O)[C:26](=[CH:30]OC)[C:27]([OH:29])=[O:28].COC=C(C)C(CC(OC)=O)=O.CCOCC>CCCCCC>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)[N:5]=[C:4]([N:18]2[C:25]([CH2:24][CH3:23])=[C:26]([C:27]([O:29][CH3:20])=[O:28])[CH:30]=[N:19]2)[N:3]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 3283Diethyl EtherHCID 18520588HCID 18520588, compoundHCID 131723912HCID 131723912, compound

Product 1

HCID 18520475HCID 18520475, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A 2.8 g portion of 4-chloro-2-hydrazino-6-(4-methoxybenzyl)aminopyrimidine was added to an ethanol solution (20 ml) of 1.72 g of methyl 2-(methoxymethylene)propionylacetate (methyl 2-methoxymethylene-3-oxopentanoate) at room temperature and stirred for 30 minutes, and then the mixture was heated under reflux for 3 hours. After concentration of the reaction solution under a reduced pressure, ether and hexane were added to the residue and the precipitate was collected by filtration to obtain 2.53 g of the title compound as a white solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-21fd2ba6de914d37aaafe8916d5558c4
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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