Ethanol → HCID 18520475, compound

Participants

Reaction Steps

A 2.8 g portion of 4-chloro-2-hydrazino-6-(4-methoxybenzyl)aminopyrimidine was added to an ethanol solution (20 ml) of 1.72 g of methyl 2-(methoxymethylene)propionylacetate (methyl 2-methoxymethylene-3-oxopentanoate) at room temperature and stirred for 30 minutes, and then the mixture was heated under reflux for 3 hours. After concentration of the reaction solution under a reduced pressure, ether and hexane were added to the residue and the precipitate was collected by filtration to obtain 2.53 g of the title compound as a white solid.

Provenance & Evidence