HCID 18520588, compound → HCID 18520406, compound

HRID 1368783Notes

Reaction equation

HRID 1368783 reaction equation
C([CH:3]([CH2:14][CH3:15])[C:4](=O)[C:5](=[CH:9][O:10][CH2:11][CH3:12])[C:6](O)=O)C.C([O:18]C=C(CC)C(CC(OCC)=O)=O)C.[Cl:31][C:32]1[CH:37]=[C:36]([NH:38][CH2:39][C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][CH:41]=2)[N:35]=[C:34]([NH:48][NH2:49])[N:33]=1>>[Cl:31][C:32]1[CH:37]=[C:36]([NH:38][CH2:39][C:40]2[CH:41]=[CH:42][C:43]([O:46][CH3:47])=[CH:44][CH:45]=2)[N:35]=[C:34]([N:48]2[C:4]([CH2:3][CH2:14][CH3:15])=[C:5]([C:9]([O:10][CH2:11][CH3:12])=[O:18])[CH:6]=[N:49]2)[N:33]=1

Participants

3

Reactant 2

HCID 18520588HCID 18520588, compoundHCID 131723914HCID 131723914, compound

Product 1

HCID 18520406HCID 18520406, compoundYield 141%

Procedure

Using 1.11 g of ethyl 2-(ethoxymethylene)butyrylacetate (ethyl 2-ethoxymethylene-3-oxohexanoate) and 1.32 g of 4-chloro-2-hydrazino-6-(4-methoxybenzyl)aminopyrimidine, the same reaction and after-treatment of Example 83-(1) were carried out to obtain 1.57 g of the title compound as a milk white solid.

Workup

  1. customthe same reaction

Sources & evidence

ORD record
ord-d47ab8aa5fff4debbf025638ab68bff5
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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