Ethanol → HCID 18520417, compound

HRID 1368784Notes

Reaction equation

HRID 1368784 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH:9][NH2:10])[N:3]=1.COC=[CH:14][CH2:15][C:16]([CH2:18][C:19]([O:21][CH3:22])=[O:20])=O.[CH2:23](O)C>>[NH2:1][C:2]1[N:3]=[C:4]([N:9]2[C:16]([CH2:15][CH3:14])=[C:18]([C:19]([O:21][CH3:22])=[O:20])[CH:23]=[N:10]2)[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 2337914-chloro-6-hydrazinylpyrimidin-2-amineHCID 131723917HCID 131723917, compound

Product 1

HCID 18520417HCID 18520417, compound

Procedure

After suspending 7.79 g portion of 2-amino-4-chloro-6-hydrazinopyrimidine in 100 ml of ethanol, 10.7 g of methyl methoxymethylenepropionylacetate was added thereto, and the mixture was stirred at room temperature for 20 minutes and then at 80° C. for 3 hours. After allowing the reaction solution to stand at 0° C. for 48 hours, the resulting precipitate was collected by filtration and dried to obtain 12.88 g of the title compound.

Workup

  1. additionwas added
  2. waitat 80° C. for 3 hours
  3. waitto stand at 0° C. for 48 hours
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-919389d36ef249daa925cd1b612f50af
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Reaction notes

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