HCID 6993440, compound → HCID 100979516, compound

HRID 1368803Notes

Reaction equation

HRID 1368803 reaction equation
[NH:1]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C@H:2]([C:4]([NH:6][C@H:7]([C:9]([NH2:11])=[O:10])C)=[O:5])[CH3:3]>CO>[NH:1]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C@H:2]([C:4]([NH:6][CH2:7][C:9]([NH2:11])=[O:10])=[O:5])[CH2:3][CH2:3][CH2:2][CH2:4][NH2:6]

Participants

3

Reactant 1

HCID 6993440HCID 6993440, compound

Product 1

HCID 100979516HCID 100979516, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Z-L-Ala-L-Ala-NH2 (12) (Katakai et al., Macromolecules, 6:827-831 (1973), which is hereby incorporated by reference): 1H NMR (DMSO-d6) δ1.20 (2×d, J=7 Hz, 6H, 2×CH3), 4.10, 4.20 (m, 2H, 2×NHCHCO), 5.00 (s, 2H, OCH2Ph), 7.20-7.40 (m, 5H, Ph); 13C NMR (DMSO-d6) δ18.1, 18.4, 47.9, 50.1, 65.4, 127.7, 128.4, 137.0, 155.8, 172.0. 174.1. HRMS (FAB+) MH+ calcd 294.1454 found 294.1457. [α]25D=−20.4 (c 0.77, MeOH).

Sources & evidence

ORD record
ord-20596299572e480697f105dc5850dea0
Source dataset
uspto-grants-2003_06
Patent number
US06576454B2

Reaction notes

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