反应详情

温度

80 °C

At about 0-5° C. under a protective atmosphere, 37.5 g (0.11 mol) of the benzophenone derivative from Example 1a in 100 ml of dimethoxyethane were added to a solution of 2.6 g (110 mol) of sodium in 50 ml of methanol. After about 72 hours of stirring at 80° C., the title compound was precipitated by adding a 1:1 mixture of water and ethyl acetate. 33.4 g (100% of theory) of product of m.p. 158° C. were isolated by filtration.

1. customthe title compound was precipitated
2. additionby adding
3. additiona 1:1 mixture of water and ethyl acetate
4. custom33.4 g (100% of theory) of product of m.p. 158° C. were isolated by filtration