Ethyl Acetate → HCID 22507055, compound

HRID 1368849Notes

Reaction equation

HRID 1368849 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]2[CH:17]=[CH:16][C:15](C)=[CH:14][C:13]=2[N+:19]([O-])=O)[N:4]=1.[H][H].[C:24](OCC)(=O)C>[C].[Pd]>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([NH:11][C:12]2[C:13]([NH2:19])=[CH:14][CH:15]=[C:16]([CH3:24])[CH:17]=2)[N:6]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 12056935HCID 12056935, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22507055HCID 22507055, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

N-(4,6-dimethoxypyrimidin-2-yl)-4-methyl-2-nitroaniline (37.50 g) was dissolved in ethyl acetate (600 ml), and 10% palladium carbon (3.75 g) was added thereto. Stirring was carried out at room temperature under normal pressure in an atmosphere of hydrogen for 4 hours, followed by filtration. The solvent of the filtrate was distilled off to obtain 32.70 g of the desired product as a white powder (m.p. 128-129° C.).

Workup

  1. filtrationfollowed by filtration
  2. distillationThe solvent of the filtrate was distilled off

Sources & evidence

ORD record
ord-8d90b1406fce4642b290f8be078f5dd2
Source dataset
uspto-grants-2003_06
Patent number
US06576631B1

Reaction notes

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