Water → HCID 18518179, compound

Participants

Reaction Steps

A mixture of 1-butyl4-piperidone (10.5 g, 67.6 mmol), pyrrolidine (6.73 g, 94.7 mmol), amberlyst-15 (200 mg) and toluene (100 ml) was stirred at reflux overnight, with a Dean and Stark water collector connected. The crude mixture was co-evaporated with toluene twice (100 ml). The product was isolated as an oil in quantitative yield.

Provenance & Evidence