Water → HCID 18518179, compound

HRID 1368901Notes

Reaction equation

HRID 1368901 reaction equation
[CH2:1]([N:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1.O>C1(C)C=CC=CC=1>[CH2:1]([N:5]1[CH2:10][CH:9]=[C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 962WaterHCID 31268PyrrolidineHCID 899951-Butyl-4-piperidone

Product 1

HCID 18518179HCID 18518179, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A mixture of 1-butyl4-piperidone (10.5 g, 67.6 mmol), pyrrolidine (6.73 g, 94.7 mmol), amberlyst-15 (200 mg) and toluene (100 ml) was stirred at reflux overnight, with a Dean and Stark water collector connected. The crude mixture was co-evaporated with toluene twice (100 ml). The product was isolated as an oil in quantitative yield.

Workup

  1. customThe product was isolated as an oil in quantitative yield

Sources & evidence

ORD record
ord-49f0552546d44975b0453cdd946289ee
Source dataset
uspto-grants-2003_06
Patent number
US06576641B2

Reaction notes

Loading…