Methanesulfonic Acid → HCID 86759006, compound

HRID 1368909Notes

Reaction equation

HRID 1368909 reaction equation
FC(F)(F)C(O)=O.[N+:8]([C:11]1[CH:12]=[C:13]([CH:17]([NH:22][C:23](=[O:40])[CH2:24][NH:25][C:26](=[O:39])[CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]2[CH:37]=[C:36]([CH3:38])[CH:35]=[CH:34][N:33]=2)[CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:15][CH:16]=1)([O-:10])=[O:9].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43]>O>[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].[N+:8]([C:11]1[CH:12]=[C:13]([CH:17]([NH:22][C:23](=[O:40])[CH2:24][NH:25][C:26](=[O:39])[CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]2[CH:37]=[C:36]([CH3:38])[CH:35]=[CH:34][N:33]=2)[CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:15][CH:16]=1)([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 70011801HCID 70011801, compound

Product 1

HCID 86759006HCID 86759006, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 mmol of 3-(3-nitrophenyl)-3-{2-[5-(4-methylpyridin-2-ylamino)pentanoylamino]acetylamino}propionic acid trifluoroacetate from Example 6 is dissolved in 10 ml of water, and methanesulfonic acid is added dropwise. The solution is freeze dried. 3-(3-nitrophenyl)-3-{2-[5-(4-methylpyridin-2-ylamino)pentanoylamino]acetylamino}propionic acid methanesulfonate is obtained.

Workup

  1. customdried

Sources & evidence

ORD record
ord-e991c378542b40baa66c39b1ea2c140a
Source dataset
uspto-grants-2003_06
Patent number
US06576637B1

Reaction notes

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