2H-Pyran, tetrahydro-2-(2-iodoethoxy)- → HCID 86590392, compound

HRID 1368946Notes

Reaction equation

HRID 1368946 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:13][CH:12]=1)=[O:10].[O:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]1[O:32][CH2:33][CH2:34]I>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH2:34][CH2:33][O:32][CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][O:26]1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)=[CH:13][CH:12]=1)=[O:10]

Participants

3

Reactant 2

HCID 111186622H-Pyran, tetrahydro-2-(2-iodoethoxy)-HCID 69544513HCID 69544513, compound

Product 1

HCID 86590392HCID 86590392, compound

Procedure

2-(2-Chlorophenyl-1-[4-(2-piperidinylethoxy)phenyl]-4-(tetrahydropyranyloxy)butan-1-one is prepared by PTC reaction according to the method described in the example 4d using 2-(2-chlorophenyl)-1-[4-(2-piperidinylethoxy)phenyl]ethanone (1.5 g, 4.2 mmol) and 2-tetrahydropyranyloxy-1-iodoethane (1.3 g, 5.1 mmol) as the starting materials. The product (1.6 g) is used for the following reaction step without further purification.

Sources & evidence

ORD record
ord-d591a31d519147859c1f013c4935cb1d
Source dataset
uspto-grants-2003_06
Patent number
US06576645B1

Reaction notes

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