Methanone, (4-nitrophenyl)phenyl- → 4-Aminobenzophenone

HRID 1368947Notes

Reaction equation

HRID 1368947 reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1)([O-])=O>C(O)C.ClCCl.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:16][CH:17]=1

Participants

4

Reactant 1

HCID 70839Methanone, (4-nitrophenyl)phenyl-

Product 1

HCID 143464-Aminobenzophenone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584144Dichloromethane ethanolSolvent

Procedure

4-Nitrobenzophenone (5.0 g, 0.022 mol) is dissolved in ethanol-dichloromethane (40 ml:30 ml) and hydrogenated at room temperature with 10% palladium on carbon (0.5 g) as a catalyst. The catalyst is filtered off and the filtrate is evaporated to dryness. The product is used in the next reaction step without further purification. Yield 5.2 g.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated to dryness
  3. customThe product is used in the next reaction step without further purification

Sources & evidence

ORD record
ord-6739355601ed42fb8d669827d530fd96
Source dataset
uspto-grants-2003_06
Patent number
US06576645B1

Reaction notes

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