2H-Pyran, tetrahydro-2-(2-iodoethoxy)- → 1-{4-[2-(2-Benzyloxyethoxy)ethoxy]phenyl}-2-phenyl-4-(tetrahydropyran-2-yloxy)butan-1-one

HRID 1368951Notes

Reaction equation

HRID 1368951 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:29])[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:17][CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH:31]1[O:36][CH2:37][CH2:38]I>>[CH2:1]([O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21](=[O:29])[CH:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:38][CH2:37][O:36][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][O:30]2)=[CH:19][CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 111186622H-Pyran, tetrahydro-2-(2-iodoethoxy)-HCID 225045131-{4-[2-(2-Benzyloxyethoxy)ethoxy]phenyl}-2-phenylethanone

Product 1

HCID 225046131-{4-[2-(2-Benzyloxyethoxy)ethoxy]phenyl}-2-phenyl-4-(tetrahydropyran-2-yloxy)butan-1-one

Procedure

is prepared by using the method described in the example 4d starting from 1-{4-[2-(2-benzyloxyethoxy)ethoxy]phenyl}-2-phenylethanone (8.4g, 21.5 mmol) and 2-(tetrahydropyran-2-yloxy)ethyl iodide (6.6 g, 25.8 mmol). The product (11.7 g) is used in the next reaction step without further purification.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-5c73fdff31a3442299357adc639cd053
Source dataset
uspto-grants-2003_06
Patent number
US06576645B1

Reaction notes

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