Acetic acid, azido-, ethyl ester → HCID 59648496, compound

HRID 1368976Notes

Reaction equation

HRID 1368976 reaction equation
[F:1][C:2]1[S:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12](=[O:17])[CH2:13][N:14]=[N+]=[N-])[CH3:10]>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[NH:14][C:4]2[CH:3]=[C:2]([F:1])[S:6][C:5]=2[CH:7]=1)=[O:17])[CH3:10]

Participants

4

Reactant 2

HCID 69480Acetic acid, azido-, ethyl esterHCID 147881815-Fluorothiophene-2-carbaldehyde

Product 1

HCID 59648496HCID 59648496, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Fluoro-thiophene-2-carbaldehyde (see, for example, Schuetz, R. D. and Nilles, G. P., J. Org. Chem., 36: 2188-90 (1971)) was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (0.6 M of ester); acrylate organic phase washed with saturated aqueous NaCl prior to drying; acrylate not purified).

Workup

  1. washacrylate organic phase washed with saturated aqueous NaCl
  2. customto drying
  3. customacrylate not purified)

Sources & evidence

ORD record
ord-d13f738fdade488f9f6de23d5b82b5c2
Source dataset
uspto-grants-2003_06
Patent number
US06576653B2

Reaction notes

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