Lithium hydroxide, monohydrate → 3-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

HRID 1368983Notes

Reaction equation

HRID 1368983 reaction equation
C([O:3][C:4]([C:6]1[NH:10][C:9]2[C:11]([Br:14])=[CH:12][S:13][C:8]=2[CH:7]=1)=[O:5])C.O[Li].O>>[Br:14][C:11]1[C:9]2[NH:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=2[S:13][CH:12]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 6487597HCID 6487597, compound

Product 1

HCID 225564983-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Procedure

3-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester was hydrolyzed according to Procedure F (7 equiv LiOH—H2O; room temperature overnight, then at 50° C. overnight again; acidified aqueous phase extracted with ethyl acetate; combined organic phases dried over MgSO4, concentrated).

Workup

  1. customroom temperature overnight
  2. customat 50° C.
  3. customovernight
  4. extractionacidified aqueous phase extracted with ethyl acetate
  5. dry with materialcombined organic phases dried over MgSO4
  6. concentrationconcentrated)

Sources & evidence

ORD record
ord-2a1d2b3f25b74fdc9ee4503292f0407e
Source dataset
uspto-grants-2003_06
Patent number
US06576653B2

Reaction notes

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