HCID 23567163, compound → HCID 23567164, compound

HRID 1369002Notes

Reaction equation

HRID 1369002 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]=[C:10]2[C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1>[Pd]>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[C:13]([O:15][CH3:16])=[O:14])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 23567163HCID 23567163, compound

Product 1

HCID 23567164HCID 23567164, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The sub-title compound was prepared according to the method described in Example 1(iv) above from 7-methoxy-3,4-dihydronaphthalen-1-yl-carboxylic acid, methyl ester (3.3 g; 15 mmol; see Example 9(i) above) and Pd/C (10%; 0.5 g). The resultant mixture was filtered through Hyflo and concentrated. The crude product was purified using flash chromatography (Si-gel; heptane:EtOAc; 4:1). Yield 2.4 g (72%).

Workup

  1. filtrationThe resultant mixture was filtered through Hyflo
  2. concentrationconcentrated
  3. customThe crude product was purified

Sources & evidence

ORD record
ord-ceed51625d774a7a8d7aeb74e7cc891e
Source dataset
uspto-grants-2003_06
Patent number
US06576657B2

Reaction notes

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