Allyl bromide → HCID 18518692, compound

HRID 1369008Notes

Reaction equation

HRID 1369008 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][CH:10]2[C:13]([O:15]C)=[O:14])=[CH:5][CH:4]=1.[H-].[Na+].[CH2:19](Br)[CH:20]=[CH2:21].[OH-].[K+]>CCO.O>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2([C:13]([OH:15])=[O:14])[CH2:21][CH:20]=[CH2:19])=[CH:5][CH:4]=1

Participants

7

Reactant 4

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 24758Sodium hydrideHCID 23567164HCID 23567164, compound

Product 1

HCID 18518692HCID 18518692, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The sub-title compound was prepared according to the method described in Example 10(ii) above from 7-methoxytetralin-1-yl-carboxylic acid, methyl ester (0.80 g; 3.6 mmol; see Example 10(i) above), NaH (55% in oil; 0.23 mg; 5.4 mmol), and allyl bromide (0.65 g, 5.4 mmol), whereafter the crude product was hydrolysed directly according to the method described in Example 10(iii) above with KOH (3 g) in EtOH:H2O (40 mL; 1:1). Yield 0.39 g (44%).

Sources & evidence

ORD record
ord-3bdd8c09f0ed4e95b42a9cbe98449ed4
Source dataset
uspto-grants-2003_06
Patent number
US06576657B2

Reaction notes

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