Lithium hydroxide, monohydrate → HCID 18518700, compound

Participants

Reaction Steps

A solution of LiOH.H2O (0.78 g; 18.6 mmol) in water (15 mL) was added to a solution of 4-hydroxy-6-methylchroman-4-yl-carboxylic acid, methyl ester (2.2 g; 9.3 mmol; from step (i) above) in THF (10 mL). The reaction mixture was stirred at room temperature overnight, THF was evaporated and the water phase was washed with ether. The resultant solution was acidified with HCl (2M) and extracted with ether. The organic layer was dried (Na2SO4) and evaporated, yielding the sub-title compound. Yield: 1.21 mg (62%).

Provenance & Evidence