Lithium hydroxide, monohydrate → HCID 18518700, compound

HRID 1369015Notes

Reaction equation

HRID 1369015 reaction equation
O[Li].O.[OH:4][C:5]1([C:16]([O:18]C)=[O:17])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:15])[CH:13]=2)[O:8][CH2:7][CH2:6]1>O.C1COCC1>[OH:4][C:5]1([C:16]([OH:18])=[O:17])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:15])[CH:13]=2)[O:8][CH2:7][CH2:6]1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 131464521HCID 131464521, compound

Product 1

HCID 18518700HCID 18518700, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of LiOH.H2O (0.78 g; 18.6 mmol) in water (15 mL) was added to a solution of 4-hydroxy-6-methylchroman-4-yl-carboxylic acid, methyl ester (2.2 g; 9.3 mmol; from step (i) above) in THF (10 mL). The reaction mixture was stirred at room temperature overnight, THF was evaporated and the water phase was washed with ether. The resultant solution was acidified with HCl (2M) and extracted with ether. The organic layer was dried (Na2SO4) and evaporated, yielding the sub-title compound. Yield: 1.21 mg (62%).

Workup

  1. customTHF was evaporated
  2. washthe water phase was washed with ether
  3. extractionextracted with ether
  4. dry with materialThe organic layer was dried (Na2SO4)
  5. customevaporated

Sources & evidence

ORD record
ord-d89815ba7a7345e9ace6236adf76f888
Source dataset
uspto-grants-2003_06
Patent number
US06576657B2

Reaction notes

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