HRID1369070

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCN(CC)CCN1C(=O)C(O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)OC(C)(C)C)cc2C(F)(F)F

HCID18518554

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCN1C(=O)C(O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)O)cc2C(F)(F)F

HCID18518549

未命名化合物

收率 85.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Treating 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-(4-t-butoxycarbonyl-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole (25.5 mg, 0.0429 mmol) with 4 N HCl in dioxane (1 mL) at 50° C. for 2 h followed by evaporation of the solvent to dryness gave the title compound (19.7 mg, 80%).

WORKUP

后处理

customfollowed by evaporation of the solvent to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3eb17c2270d5463e9e789c601c67075e
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06576656B1
来源说明: uspto-grants-2003_06

反应 SMILES

[CH2:1]([N:3]([CH2:42][CH3:43])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:26]([F:29])([F:28])[F:27])[CH:11]=[C:12]([C:15]#[C:16][CH2:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[CH:13]=2)[C:8]([OH:40])([C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)[C:7]1=[O:41])[CH3:2].Cl>O1CCOCC1>[CH2:42]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:26]([F:28])([F:27])[F:29])[CH:11]=[C:12]([C:15]#[C:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:13]=2)[C:8]([OH:40])([C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)[C:7]1=[O:41])[CH3:43]