HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-carboxy-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-t-butoxycarbonyl-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole | HCID 18518554 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-carboxy-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole | HCID 18518549 | 85,3% |
Reaktionsschritte
Treating 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-(4-t-butoxycarbonyl-1-butynyl)-3-hydroxy-3-(2-naphthyl)oxindole (25.5 mg, 0.0429 mmol) with 4 N HCl in dioxane (1 mL) at 50° C. for 2 h followed by evaporation of the solvent to dryness gave the title compound (19.7 mg, 80%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06576656B1 |
| Quelldatensatz | uspto-grants-2003_06 |
| ORD ID | ord-3eb17c2270d5463e9e789c601c67075e |
| Quellennotiz | uspto-grants-2003_06 |