Hydrochloric Acid → N-(4-fluorophenyl)-N'-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]cyclopropane-1,1-dicarboxamide

HRID 136911Notes

Reaction equation

HRID 136911 reaction equation
[ClH:39].[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9](=[O:10])[C:11]2([C:14](=[O:15])[NH:16][c:17]3[cH:18][cH:19][c:20]([O:23][c:24]4[c:25]5[c:26]([n:27][cH:28][n:29]4)[n:30]([CH:33]4[CH2:34][CH2:35][CH2:36][CH2:37][O:38]4)[n:31][cH:32]5)[cH:21][cH:22]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1.[O:40]1[CH2:41][CH2:42][O:43][CH2:44][CH2:45]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][C:9](=[O:10])[C:11]2([C:14](=[O:15])[NH:16][c:17]3[cH:18][cH:19][c:20]([O:23][c:24]4[c:25]5[c:26]([n:27][cH:28][n:29]4)[nH:30][n:31][cH:32]5)[cH:21][cH:22]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 11699227N-(4-fluorophenyl)-N'-(4-{[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide

Product 1

HCID 11590092N-(4-fluorophenyl)-N'-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]cyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-234f65df3c314f8e8f40eda7980d1fad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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