2-Bromo-1,4-dichlorobenzene → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2,5-dichlorophenyl)oxindole

HRID 1369110Notes

Reaction equation

HRID 1369110 reaction equation
[CH2:1]([N:3]([CH2:22][CH3:23])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:21])([F:20])[F:19])[CH:13]=[C:14]([I:17])[CH:15]=2)[C:9](=[O:10])[C:7]1=[O:8])[CH3:2].[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1Br>>[CH2:22]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:20])([F:21])[F:19])[CH:13]=[C:14]([I:17])[CH:15]=2)[C:9]([OH:10])([C:29]2[CH:30]=[C:25]([Cl:24])[CH:26]=[CH:27][C:28]=2[Cl:31])[C:7]1=[O:8])[CH3:23]

Participants

3

Reactant 2

HCID 150332-Bromo-1,4-dichlorobenzeneHCID 110265521-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin

Product 1

HCID 185185721-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2,5-dichlorophenyl)oxindoleYield 51%

Procedure

The title compound (137 mg, 51%) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin (200 mg, 0.454 mmol) and 2,5-dichlorobromobenzene by the procedure similar to that described Example 92(1).

Sources & evidence

ORD record
ord-b198b6049c38420b97ca8dfe3c565b49
Source dataset
uspto-grants-2003_06
Patent number
US06576656B1

Reaction notes

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