HRID1369121

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13765095

未命名化合物

结构：CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(I)cc2C(F)(F)F

HCID18518612

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F

HCID18518645

未命名化合物

收率 106%

PROCEDURE

实验过程

The title compound (65.2 mg, 88%) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole (57.2 mg) and 4-morpholinocarbonyl-1-butyne (31.1 mg) by the procedure similar to that described in Reference Example 21. The compound obtained was further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid.

WORKUP

后处理

customThe compound obtained
customwas further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f79933e9a2c4693b8b42bebe055deec
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06576656B1
来源说明: uspto-grants-2003_06

反应 SMILES

[CH2:1]([N:3]([CH2:28][CH3:29])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12](I)[CH:13]=2)[C:8]([OH:26])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:7]1=[O:27])[CH3:2].[O:30]1[CH2:35][CH2:34][N:33]([C:36]([CH2:38][CH2:39][C:40]#[CH:41])=[O:37])[CH2:32][CH2:31]1>>[CH2:1]([N:3]([CH2:28][CH3:29])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12]([C:41]#[C:40][CH2:39][CH2:38][C:36]([N:33]3[CH2:34][CH2:35][O:30][CH2:31][CH2:32]3)=[O:37])[CH:13]=2)[C:8]([OH:26])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:7]1=[O:27])[CH3:2]