HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Morpholinocarbonyl-1-butyne → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-morpholinocarbonyl-1-butynyl)-3-hydroxy-3-(phenyl)oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Morpholinocarbonyl-1-butyne | HCID 13765095 | — |
| Reactant | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole | HCID 18518612 | — |
| Product | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(4-morpholinocarbonyl-1-butynyl)-3-hydroxy-3-(phenyl)oxindole | HCID 18518645 | 106% |
Reaction Steps
The title compound (65.2 mg, 88%) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole (57.2 mg) and 4-morpholinocarbonyl-1-butyne (31.1 mg) by the procedure similar to that described in Reference Example 21. The compound obtained was further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576656B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-1f79933e9a2c4693b8b42bebe055deec |
| Source note | uspto-grants-2003_06 |