Hydrochloric Acid → HCID 10303207, compound

HRID 1369156Notes

Reaction equation

HRID 1369156 reaction equation
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([C:13]([CH3:39])([CH3:38])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH:32]3O)=[CH:22][C:23]=2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH3:17])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Cl>C(Cl)(Cl)Cl.C(OCC)C>[F:41][C:2]([F:1])([F:40])[C:3]1[CH:4]=[C:5]([C:13]([CH3:39])([CH3:38])[C:14]([N:16]([C:18]2[CH:19]=[N:20][C:21]([N:31]3[CH:32]=[CH:33][O:34][CH2:35][CH2:36]3)=[CH:22][C:23]=2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH3:17])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:10])[F:11])[CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22992335HCID 22992335, compound

Product 1

HCID 10303207HCID 10303207, compoundYield 75.8%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

To a solution of 65 mg (0.11 mmol) (RS)-2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(3-hydroxy-morpholin-4-yl)-4-o-tolyl-pyridin-3-yl]-N-methyl-isobutyramide in 2 ml chloroform were added a few drops of a 2.3 N hydrochloric acid solution in diethyl ether. After stirring at room temperature for 2 h, the organic layer was washed with saturated sodium carbonate solution, dried (magnesium sulfate) and evaporated. The residue was purified by flash-chromatography to give 47 mg (75%) of the title compound as white foam.

Workup

  1. washthe organic layer was washed with saturated sodium carbonate solution
  2. dry with materialdried (magnesium sulfate)
  3. customevaporated
  4. customThe residue was purified by flash-chromatography

Sources & evidence

ORD record
ord-8f7af2dd4c2b4652b24bca28e9750a15
Source dataset
uspto-grants-2003_06
Patent number
US06576762B2

Reaction notes

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