Ethyl (+/-)-10,11 dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate → Ethyl (+/-)-10,11-dihydro-3-hydroxy-6-methyl-5H-dibenzo[a,d]cycloheptene-10-acetate

HRID 1369222Notes

Reaction equation

HRID 1369222 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10]3[CH:19]=[CH:20][CH:21]=[C:22]([CH3:23])[C:9]=3[CH2:8][C:7]=2[CH:24]=1.COC1C=CC2CC(CC(OCC)=O)C3C=CC=CC=3CC=2C=1>CO>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10]3[CH:19]=[CH:20][CH:21]=[C:22]([CH3:23])[C:9]=3[CH2:8][C:7]=2[CH:24]=1

Participants

4

Reactant 2

HCID 15462070Ethyl (+/-)-10,11 dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetateHCID 86585473Ethyl (+/-)-10,11-dihydro-3-methoxy-6-methyl-5H-dibenzo[a,d]cycloheptene-10-acetate

Product 1

HCID 53895967Ethyl (+/-)-10,11-dihydro-3-hydroxy-6-methyl-5H-dibenzo[a,d]cycloheptene-10-acetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure of Preparation 10 (g), except substituting ethyl (±)-10,11-dihydro-3-methoxy-6-methyl-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (±)-10,11-dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as a white solid after trituration with MeOH: MS (ES) m/e 311.2 (M+H)+.

Sources & evidence

ORD record
ord-96e16f48f00b4927b396d3ef3ba23f21
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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