HCID 11403711, compound → HCID 53773271, compound

HRID 1369243Notes

Reaction equation

HRID 1369243 reaction equation
OCC[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N+:7]=1[O-].[OH:13][C:14]1[CH:15]=[CH:16][C:17]2[CH2:23][C@@H:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:21]3[CH:30]=[CH:31][CH:32]=[CH:33][C:20]=3[CH2:19][C:18]=2[CH:34]=1.O[C:36]1C=CC2C[C@H](CC(OCC)=O)C3C=CC=CC=3CC=2[CH:56]=1>>[CH3:4][NH:5][C:6]1[N:7]=[C:8]([CH2:36][CH2:56][O:13][C:14]2[CH:15]=[CH:16][C:17]3[CH2:23][C@@H:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[C:21]4[CH:30]=[CH:31][CH:32]=[CH:33][C:20]=4[CH2:19][C:18]=3[CH:34]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 11403711HCID 11403711, compoundHCID 12071476HCID 12071476, compoundHCID 178526251HCID 178526251, compound

Product 1

HCID 53773271HCID 53773271, compound

Procedure

According to the procedure of Example 6 (a), except substituting 6-(methylamino)-2-pyridylethanol for the 2-[(3-hydroxy-1-propyl)amino]pyridine-N-oxide, and ethyl (S)-10,11-dihydro-3-hydroxy-5H-dibenzo[a,d]cycloheptene-10-acetate for ethyl (R)-10,11-dihydro-3-hydroxy-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as colorless oil following silica gel chromatography (0.2-2% MeOH/CH2Cl2): MS (ES) 431.2 (M+H)+.

Sources & evidence

ORD record
ord-1d4065fec53d49b588cf5e3d41ae7524
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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