HCID 12071478, compound → HCID 18518262, compound

HRID 1369249Notes

Reaction equation

[CH2:1]([S:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]3[CH2:24][CH:23]([CH2:25][C:26]([O:28]CC)=[O:27])[C:22]4[CH:31]=[CH:32][CH:33]=[CH:34][C:21]=4[CH2:20][C:19]=3[CH:35]=2)[CH:5]=1)[CH3:2].N1C=CC=CC=1NCCCOC1C=CC2C[C@H](CC(OCC)=O)C3C=CC=CC=3CC=2C=1>>[CH2:1]([S:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]3[CH2:24][CH:23]([CH2:25][C:26]([OH:28])=[O:27])[C:22]4[CH:31]=[CH:32][CH:33]=[CH:34][C:21]=4[CH2:20][C:19]=3[CH:35]=2)[CH:5]=1)[CH3:2]

Participants

Reactant 2

HCID 12071478HCID 12071478, compound

HCID 86585476HCID 86585476, compound

Product 1

HCID 18518262HCID 18518262, compound

Procedure

According to the procedure of Example 6 (c), except substituting ethyl (±)-10,11-dihydro-3-[3-[4-(ethylthio)pyridin-2-y lamino]-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (R)-10,11-dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was prepared as a yellow: 1H NMR (400 MHz, DMSO-d6) δ7.77-7.76 (d, 1 H), 7.17-7.15 (d, 1 H), 7.13-7.12 (d, 2 H), 7.08-7.07 (m, 1 H), 6.96-6.94(d, 1 H), 6.81-6.80 (s, 1 H), 6.68-6.67 (d, 1 H), 6.52 (s, 1 H), 6.35-6.33 (d, 2 H), 6.30 (s, 1 H), 4.20-4.16 (d, 1 H), 3.99-3.96 (t, 2 H),3.89-3.85 (d, 1 H), 3.65-3.63 (m, 1 H), 3.36-3.32 (m, 2 H), 3.22-3.15 (m, 1 H), 2.96-2.90 (m, 2 H); 2.85-2.78 (m, 1 H), 2.62-2.56(m, 2 H), 1.94-1.90(m, 2 H), 1.26-1.22 (t, 3 H), MS (ES) m/e463.4(M+H)+.

Sources & evidence

ORD record: ord-b6460fc275a349e2928fb1f1754b6e4f
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06576643B2

Reaction notes

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