HCID 12071478, compound → HCID 18518253, compound

HRID 1369250Notes

Reaction equation

HRID 1369250 reaction equation
[CH3:1][C:2]1[C:22]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)=[CH:21][C:5]2[CH2:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([CH2:11][C:12]([O:14]CC)=[O:13])[CH2:10][C:4]=2[CH:3]=1.N1C=CC=CC=1NCCCOC1C=CC2C[C@H](CC(OCC)=O)C3C=CC=CC=3CC=2C=1>>[CH3:1][C:2]1[C:22]([O:23][CH2:24][CH2:25][CH2:26][NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)=[CH:21][C:5]2[CH2:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([CH2:11][C:12]([OH:14])=[O:13])[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 12071478HCID 12071478, compoundHCID 20592633HCID 20592633, compound

Product 1

HCID 18518253HCID 18518253, compound

Procedure

According to the procedure of Example 6 (c), except substituting ethyl (±)-10,11-dihydro-2-methyl-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (R)-10,11-dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as an off white solid. 1H NMR (400 MHz, CDCl3) δ7.75 (d, 1 H), 7.65 (t, 1 H), 7.15 (m, 3 H), 7.05 (m, 1 H), 6.83 (s, 1 H), 6.7 (d, 1 H), 6.65 (m, 1 H), 6.60 (s,1 H), 4.25 (d, J=15.1 Hz, 1 H), 4.05 (t, 2 H), 3.80 (m, 1 H), 3.75 (d, J=15.1 Hz, 1 H), 3.50 (t, 2 H), 3.25 (dd, 1 H), 2.85 (dd, 1 H), 2.68 (dd, 1 H), 2.60 (dd, 1 H), 2.15 (t, 2 H), 2.10 (s, 3 H); MS (ES) m/e 417.3 (M+H)+.

Sources & evidence

ORD record
ord-27163b5314724aa0972e7ecb3ea360cf
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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