反应详情

A mixture of 7-benzyloxycarbonyl-1-methoxynaphtho[1,2-c]furan-3(1H)-one (33 mg, 0.095 mmol) and a catalytic amount of 10% Pd/C in 2 mL of EtOH was stirred at rt under an atmosphere of H2 (balloon) for 2 h. The mixture was then diluted with THF and filtered through a pad of Celite. The filtrate was then concentrated in vacuo. The crude material was dissolved in saturated aqueous NaHCO3 and washed with EtOAc. The aqueous layer was then acidified with 1 M aqueous HCl and extracted with EtOAc. The extract was dried over MgSO4 and concentrated in vacuo affording 19 mg (79%).

1. filtrationfiltered through a pad of Celite
2. concentrationThe filtrate was then concentrated in vacuo
3. dissolutionThe crude material was dissolved in saturated aqueous NaHCO3
4. washwashed with EtOAc
5. extractionextracted with EtOAc
6. dry with materialThe extract was dried over MgSO4
7. concentrationconcentrated in vacuo
8. customaffording 19 mg (79%)