反应详情

To a solution of 3-acetoxy-5-formylnaphtho[2,3-c]furan-1(3H)-one (100 mg, 0.377 mmol) in MeCN (0.373 mL) and H2O (0.150 mL) at rt was added NaH2PO4 (15.3 mg, 0.097 mmol) followed by 50% H2O2 (0.026 mL). NaClO2 (1.0 M in H2O, 0.518 mL) was added over the course of 2 h via syringe pump. The reaction mixture was then diluted with saturated aqueous NH4Cl and extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated to give the title compound (87 mg, 80%).

1. extractionextracted with EtOAc
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated