反应详情

4-Bromo-2-(4-fluorophenyl)-1-(2-trimethylsilanyl-ethoxymethyl)imidazole (3.4 g; 9 mmol) is dissolved in EtOH (34 ml) and HCl conc. (37%; 34 ml) and heated to 55 C for 1 h. Water is added to the reaction mixture and the aqueous phase extracted three times with ethyl acetate. The combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution, dried over Na2SO4, filtered and evaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%).

1. extractionthe aqueous phase extracted three times with ethyl acetate
2. washThe combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%)