3,5-Difluorobenzaldehyde → 3,5-Difluorobenzaldehyde 2-(6-chloro-5-cyclobutyl-3-pyridazinyl)hydrazone

HRID 1369420Notes

Reaction equation

HRID 1369420 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:12][NH2:13])=[CH:6][C:7]=1[CH:8]1[CH2:11][CH2:10][CH2:9]1.[F:14][C:15]1[CH:16]=[C:17]([CH:20]=[C:21]([F:23])[CH:22]=1)[CH:18]=O>Cl>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:12][N:13]=[CH:18][C:17]2[CH:16]=[C:15]([F:14])[CH:22]=[C:21]([F:23])[CH:20]=2)=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 5881603,5-DifluorobenzaldehydeHCID 226099463-chloro-4-cyclobutyl-6-hydrazinylPyridazine

Product 1

HCID 739859023,5-Difluorobenzaldehyde 2-(6-chloro-5-cyclobutyl-3-pyridazinyl)hydrazone

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3-Chloro-4-cyclobutyl-6-hydrazinopyridazine (0.502 g, 2.53 mmol) and 3,5-difluorobenzaldehyde (285 ml, 2.78 mmol) were stirred in 0.2M hydrochloric acid (10 ml) for 2 hours. This product was then collected by filtration and dried (0.81 g, 99%). MS (ES+) 323 [MH]+, 325 [MH]+.

Workup

  1. filtrationThis product was then collected by filtration
  2. customdried (0.81 g, 99%)

Sources & evidence

ORD record
ord-693d4f5c71e748c89059cb346c007734
Source dataset
uspto-grants-2003_06
Patent number
US06579875B1

Reaction notes

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