Methanol → HCID 22591541, compound

HRID 1369478Notes

Reaction equation

HRID 1369478 reaction equation
[Na].CO[C:4]1[N:5]=[N:6][C:7]([S:10]([C:13]2[N:14](S(C3C=CC=CC=3)(=O)=O)[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:12])=[O:11])=[CH:8][CH:9]=1.[CH3:31][OH:32]>>[CH3:31][O:32][N:5]1[CH:4]=[CH:9][CH:8]=[C:7]([S:10]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:11])=[O:12])[NH:6]1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 22591544HCID 22591544, compound

Product 1

HCID 22591541HCID 22591541, compoundYield 82%

Procedure

To a solution of sodium metal (18.6 mmol, 428 mg) dissolved in methanol (8 mL) was added a solution of 3-methoxy-6-(N-phenylsulfonylindole-2-sulfonyl)-pyridazine (1.86 mmol, 850 mg) and the reaction was stirred for 10 minutes. The reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL). The CHCl3 layer was collected, dried, filtered, and the filtrate was evaporated to obtain 2-methoxy-6-(indole-2-sulfonyl)-pyridazine (82%, 440 mg).

Workup

  1. customThe reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL)
  2. customThe CHCl3 layer was collected
  3. customdried
  4. filtrationfiltered
  5. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-c926dda6baa34c749556eedbc773bcdb
Source dataset
uspto-grants-2003_06
Patent number
US06579879B2

Reaction notes

Loading…