Hydrochloric Acid → HCID 22591566, compound

HRID 1369482Notes

Reaction equation

HRID 1369482 reaction equation
C[O:2][C:3]1[NH:4][NH:5][C:6]([S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:16]=[CH:15]3)(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[CH2:21]([N:17]1[C:18]2[C:14](=[CH:13][C:12]([S:9]([C:6]3[CH:7]=[CH:8][C:3](=[O:2])[NH:4][N:5]=3)(=[O:11])=[O:10])=[CH:20][CH:19]=2)[CH:15]=[CH:16]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 225915483-methoxy-6-(N-benzylindole-5-sulfonyl)-2H-pyridazine

Product 1

HCID 22591566HCID 22591566, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3-methoxy-6-(N-benzylindole-5-sulfonyl)-2H-pyridazine (0.64 mmol, 245 mg), conc. HCl (0.5 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue and the resulting solid, 6-(N-benzylindole-5-sulfonyl)-2H-pyridazin-3-one, was collected (55%, 102 mg).

Workup

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. additionWater (10 mL) was added to the residue
  4. customthe resulting solid, 6-(N-benzylindole-5-sulfonyl)-2H-pyridazin-3-one, was collected (55%, 102 mg)

Sources & evidence

ORD record
ord-07f24502f27d41d6bbf07dc3fe52d4d9
Source dataset
uspto-grants-2003_06
Patent number
US06579879B2

Reaction notes

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