Iodoethane → HCID 17922784, compound

HRID 1369546Notes

Reaction equation

HRID 1369546 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[CH:11]=2)=[CH:4][C:3]=1[NH:23][C:24](=[O:36])[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:26]=1.[CH2:37](I)[CH3:38]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:22])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N:16]3[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[CH:11]=2)=[CH:4][C:3]=1[NH:23][C:24](=[O:36])[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([N:31]([S:32]([CH3:35])(=[O:33])=[O:34])[CH2:37][CH3:38])[CH:26]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 22291112HCID 22291112, compound

Product 1

HCID 17922784HCID 17922784, compoundYield 64%

Procedure

Using an analogous procedure to that described in Example 61, N-[2-methyl-5-(3-morpholinobenzamido)phenyl]-3-methanesulphonylaminobenzamide was reacted with ethyl iodide to give the title compound in 64% yield; m.p. 192-193° C.; NMR Spectrum: (DMSOd6) 1.05 (t, 3H), 2.21 (s, 3H), 3.16 (t, 4H),3.73 (m, 6H), 7.13 (m, 1H) 7.23 (d, 1H), 7.36 (m, 2H), 7.43 (d, 1H), 7.58 (m, 3H), 7.81 (d, 1H), 7.95 (m, 2H), 7.99 (d, 1H), 10.0 (s, 1H), 10.12 (s, 1H); Mass Spectrum: M+H+537.

Sources & evidence

ORD record
ord-b5fcf74a5819439c88a61032b9658473
Source dataset
uspto-grants-2003_06
Patent number
US06579872B1

Reaction notes

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