HCID 22312692, compound → HCID 86584980, compound

HRID 1369737Notes

Reaction equation

HRID 1369737 reaction equation
[CH:1]1([CH:6]([OH:10])[C:7]([OH:9])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.N[C@H](C([NH:17][CH:18]1[C:24](=[O:25])[N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:22]2[CH:32]=[CH:33][CH:34]=[CH:35][C:21]=2[N:20]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:19]1=[O:42])=O)C>>[CH:1]1([CH:6]([OH:10])[C:7]([NH:17][C@H:18]([C:24]([C:18]2([NH2:17])[C:19](=[O:42])[N:20]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:21]3[CH:35]=[CH:34][CH:33]=[CH:32][C:22]=3[N:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:24]2=[O:25])=[O:25])[CH3:19])=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 22312692HCID 22312692, compoundHCID 23552772HCID 23552772, compound

Product 1

HCID 86584980HCID 86584980, compound

Procedure

Following General Procedure I above using cyclopentyl-α-hydroxyacetic acid (Example P) and 3-(L-alaninyl)-amino-2,4-dioxo-1,5-bis-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-W), the tide compound was prepared as a white solid (melting point=139-149° C.). Purification was by flash chromatography eluting with CH2Cl2/EtOAc (1:2). Rf=0.50 and 0.39 (CH2Cl2/EtOAc, 1:2).

Workup

  1. customPurification
  2. washeluting with CH2Cl2/EtOAc (1:2)

Sources & evidence

ORD record
ord-af0f96c668fe42cea18a9588b693c2a4
Source dataset
uspto-grants-2003_06
Patent number
US06579867B2

Reaction notes

Loading…