5-Fluoroisatin → 5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1369851Notes

Reaction equation

HRID 1369851 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O>O.NN>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

Participants

3

Reactant 1

HCID 2365665-Fluoroisatin

Product 1

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Reagents, catalysts & solvents 1

HCID 24654Hydrazine hydrate (1:1)Solvent

Procedure

5-Fluoroisatin (8.2 g) was dissolved in 50 mL of hydrazine hydrate and refluxed for 1.0 hr. The reaction mixtures were then poured in ice water. The precipitate was then filtered, washed with water and dried under vacuum oven afford the title compound.

Workup

  1. temperaturerefluxed for 1.0 hr
  2. customThe reaction mixtures
  3. filtrationThe precipitate was then filtered
  4. washwashed with water
  5. customdried under vacuum oven

Sources & evidence

ORD record
ord-96928317325a48b5b564bbe9c7e39bdc
Source dataset
uspto-grants-2003_06
Patent number
US06579897B2

Reaction notes

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