HCID 21925692, compound → HCID 21925676, compound

HRID 1369899Notes

Reaction equation

HRID 1369899 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[CH:23](C(OC)=O)[C:24]([O:26]C)=[O:25])([O-:3])=[O:2]>Cl>[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17](=[O:22])[C:18]([F:19])([F:20])[F:21])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[CH2:23][C:24]([OH:26])=[O:25])([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 21925692HCID 21925692, compound

Product 1

HCID 21925676HCID 21925676, compoundYield 73.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dimethyl 2-[2-nitro-4-(3-trifluoroacetamidophenyl)phenyl]-malonate (4.4 g) was refluxed overnight in 50 mL 6N hydrochloric acid. The reaction mixture was cooled to room temperature and the solids were collected by vacuum filtration, washed with water, and dried under vacuum to give 2.7 g (73% yield) of 2-[2-nitro-4-(3-trifluoroacetamidophenyl)phenyl] acetic acid.

Workup

  1. filtrationthe solids were collected by vacuum filtration
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-6f8a912a94624e27aec93bc6b2dff3e7
Source dataset
uspto-grants-2003_06
Patent number
US06579897B2

Reaction notes

Loading…