反应详情

A solution of 60 mg (0.27 mmol) of 3a,6-difluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 15 ml of THF is mixed with 288 mg (0.71 mmol) of Lawesson's reagent and refluxed for 1.5 hours. Then, the reaction mixture is concentrated by evaporation, and the residue is purified by column chromatography on silica gel (eluant: hexane-ethyl acetate): 50 mg of product.

1. temperaturerefluxed for 1.5 hours
2. concentrationThen, the reaction mixture is concentrated by evaporation
3. customthe residue is purified by column chromatography on silica gel (eluant: hexane-ethyl acetate)