Ammonia → HCID 10221410, compound

HRID 1369914Notes

Reaction equation

HRID 1369914 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=S)[C:6]3([F:16])[CH2:13][CH2:14][CH2:15][CH:5]3[C:4]=2[CH:3]=1.[NH3:17]>>[NH2:17][C:7]1[C:6]2([F:16])[CH2:13][CH2:14][CH2:15][CH:5]2[C:4]2[CH:3]=[C:2]([Br:1])[CH:11]=[CH:10][C:9]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 18516399HCID 18516399, compound

Product 1

HCID 10221410HCID 10221410, compound

Procedure

75 mg (0.25 mmol) of 8-bromo-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione is dissolved in 20 ml of 7 M methanolic ammonia solution. After 1.5 hours of stirring at room temperature, the batch is concentrated by evaporation in a vacuum and the residue is purified by column chromatography on silica gel with ethyl acetate: 60 mg of product, melting point 220° C.

Workup

  1. concentrationthe batch is concentrated by evaporation in a vacuum
  2. customthe residue is purified by column chromatography on silica gel with ethyl acetate

Sources & evidence

ORD record
ord-4277d61ff6014fac85aa64814e3fec4c
Source dataset
uspto-grants-2003_06
Patent number
US06579883B1

Reaction notes

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