Ammonia → HCID 10221410, compound

Participants

Reaction Steps

75 mg (0.25 mmol) of 8-bromo-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione is dissolved in 20 ml of 7 M methanolic ammonia solution. After 1.5 hours of stirring at room temperature, the batch is concentrated by evaporation in a vacuum and the residue is purified by column chromatography on silica gel with ethyl acetate: 60 mg of product, melting point 220° C.

Provenance & Evidence