HCID 21933594, compound → HCID 21933604, compound

HRID 1370170Notes

Reaction equation

HRID 1370170 reaction equation
O[C:2]([CH2:4][CH2:5][S:6][C:7]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10])=[O:3]>O>[Cl:17][C:15]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]2[C:16]=1[C:2](=[O:3])[CH2:4][CH2:5][S:6]2

Participants

3

Reactant 1

HCID 21933594HCID 21933594, compound

Product 1

HCID 21933604HCID 21933604, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

At 70° C., 50 g (0.18 mol) of methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate were against [sic] to 500 g of polyphosphoric acid, and the mixture was stirred for 30 minutes. The reaction mixture was subsequently added to water with stirring, and the resulting precipitate was filtered off with suction and dried. This gave 41.1 g (88%) of methyl 5-chloro-4-oxothiochromane-8-carboxylate.

Workup

  1. customAt 70° C.
  2. stirringwith stirring
  3. filtrationthe resulting precipitate was filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-2e44bbc229df489bbbf4cbd6392fe02f
Source dataset
uspto-grants-2003_06
Patent number
US06583089B1

Reaction notes

Loading…