HCID 21933594, compound → HCID 21933604, compound

Participants

Reaction Steps

At 70° C., 50 g (0.18 mol) of methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate were against [sic] to 500 g of polyphosphoric acid, and the mixture was stirred for 30 minutes. The reaction mixture was subsequently added to water with stirring, and the resulting precipitate was filtered off with suction and dried. This gave 41.1 g (88%) of methyl 5-chloro-4-oxothiochromane-8-carboxylate.

Provenance & Evidence