反应详情

Chromatographically pure 2-amino-5-(4chlorophenoxy)-4-(trans-4-hydroxycyclohexylamino)pyrimidine (0.93 g, 2.78 mmoles) was dissolved in ethanol (10 mL), concentrated hydrochloric acid (1 mL) was added, and the solution was spin evaporated in vacuo to give a solid. The solid was triturated under ethyl acetate to give a white solid which was collected, washed with ethyl acetate and dried in vacuo to give 0.93 g (90% yield) of 2-amino-5-(4-chlorophenoxy)-4-(trans-4-hydroxycyclohexylamino)pyrimidine hydrochloride as white crystals, mp 155-156° C.

1. customevaporated in vacuo
2. customto give a solid
3. customThe solid was triturated under ethyl acetate
4. customto give a white solid which
5. customwas collected
6. washwashed with ethyl acetate
7. customdried in vacuo