Methyl iodide → HCID 9893962, compound

HRID 1370533Notes

Reaction equation

HRID 1370533 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:9][N:10]([CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH2:30][O:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH2:23][CH2:22]1)[C:11](=[N:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[S:12][CH3:13].CI>>[CH3:9][N:10]([CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH2:30][O:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH2:23][CH2:22]1)[C:11]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[S:12].[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:9][N:10]([CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][CH2:30][O:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH2:23][CH2:22]1)[C:11](=[N:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[S:12][CH3:13]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 9893962HCID 9893962, compound

Product 2

HCID 9893962HCID 9893962, compoundYield 35%HCID 18511670HCID 18511670, compound

Procedure

The S-methylation of 1.5 g (3.5 mmol) of the preceding thiourea 9.2 with 240 μl of methyl iodide according to 1.2 results in the preparation of 690 mg (Yd: 35%) of the isothiourea of formula 9:

Sources & evidence

ORD record
ord-eaeb1a7516a141b7aa0cc5a0f16ad5c0
Source dataset
uspto-grants-2003_06
Patent number
US06583159B1

Reaction notes

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