HCID 19107605, compound → HCID 18510821, compound

HRID 1370547Notes

Reaction equation

HRID 1370547 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[CH:10][C:11]#[N:12])=[CH:5][CH:4]=1>O1CCOCC1.[Pd]>[CH3:20][O:19][C:16]1[CH:15]=[CH:14][C:13]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:10][C:11]#[N:12])=[CH:18][CH:17]=1

Participants

4

Reactant 1

HCID 19107605HCID 19107605, compound

Product 1

HCID 18510821HCID 18510821, compoundYield 75.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

10% Pd-C (20 mg) was added to a solution of 3,3-bis(4-methoxyphenyl)-propenenitrile (50 mg), synthesized by the process described in a literature J. Med. Chem., 32, 1820 (1989), in dioxane (5 ml), followed by hydrogenation for 2 hr. Pd-C was removed by filtration through Celite. The solvent was then removed by distillation to give 3,3-bis(4-methoxyphenyl)-propanenitrile (38 mg).

Workup

  1. customsynthesized by the process
  2. customPd-C was removed by filtration through Celite
  3. customThe solvent was then removed by distillation

Sources & evidence

ORD record
ord-eaa29f9fd39c4d1ea7598648279cd7ae
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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