3,3-Bis(4-methoxyphenyl)-propanaldehyde → 2-Cyclohexyl-6-{4-[3,3-bis(4-methoxyphenyl)-1-propyl]-piperazin-1-yl}-2,3-dihydro-1H-isoindol-1-one

HRID 1370548Notes

Reaction equation

HRID 1370548 reaction equation
[CH:1]1([N:7]2[CH2:15][C:14]3[C:9](=[CH:10][C:11]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)=[CH:12][CH:13]=3)[C:8]2=[O:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=2)[CH2:32][CH:33]=O)=[CH:27][CH:26]=1>>[CH:1]1([N:7]2[CH2:15][C:14]3[C:9](=[CH:10][C:11]([N:16]4[CH2:17][CH2:18][N:19]([CH2:33][CH2:32][CH:31]([C:28]5[CH:27]=[CH:26][C:25]([O:24][CH3:23])=[CH:30][CH:29]=5)[C:35]5[CH:36]=[CH:37][C:38]([O:41][CH3:42])=[CH:39][CH:40]=5)[CH2:20][CH2:21]4)=[CH:12][CH:13]=3)[C:8]2=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 132994923,3-Bis(4-methoxyphenyl)-propanaldehydeHCID 22180413HCID 22180413, compound

Product 1

HCID 185109242-Cyclohexyl-6-{4-[3,3-bis(4-methoxyphenyl)-1-propyl]-piperazin-1-yl}-2,3-dihydro-1H-isoindol-1-oneYield 59.8%

Procedure

In the same manner as in Example 38, the title compound (52 mg) was prepared from the compound (47 mg) obtained in step (e) of Example 1 and the compound (110 mg) obtained in step (b).

Sources & evidence

ORD record
ord-e7a924eea7e446dc890bdc3590937677
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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