Bromocycloheptane → 2-Cycloheptyl-6-[4-(3,3-diphenyl-1-propyl)-piperazin-1-yl]-2,3-dihydro-1H-isoindol-1-one

HRID 1370559Notes

Reaction equation

HRID 1370559 reaction equation
[C:1]1([CH:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH2:20][NH:21][C:22]4=[O:25])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:32]1(Br)[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:32]1([N:21]2[CH2:20][C:19]3[C:23](=[CH:24][C:16]([N:13]4[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[CH2:15][CH2:14]4)=[CH:17][CH:18]=3)[C:22]2=[O:25])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 16992BromocycloheptaneHCID 185109312,3-Dihydro-6-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-1H-isoindol-1-one

Product 1

HCID 185109402-Cycloheptyl-6-[4-(3,3-diphenyl-1-propyl)-piperazin-1-yl]-2,3-dihydro-1H-isoindol-1-oneYield 19.5%

Procedure

In the same manner as in Example 51, the title compound (12 mg) was prepared from the compound (50 mg) obtained in Example 50 and cycloheptyl bromide (32 mg).

Sources & evidence

ORD record
ord-aba4e8f4dfb240a48b2c666620b48196
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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